Exploring a possible link between insulin resistance, vaccine to SARS CoV 2 and glycaemic disturbances in diabetes mellitus, type 2

The occurrence of both hyperglycaemia and hypoglycaemia, individually in combination is reported the literature, occurring various insulin resistance (IR) syndromes, to endogenous insulin, like Hirata disease, otherwise called Insulin Autoimmune syndrome (IAS), type A, I R, Type B, IR etc. exogenous administered like, antibody syndrome, (EIAS), non- classical auto immune Glycaemic disturbances without non-diabetics, idiopathic symptomatic reactive hypoglycaemias are also described literature. This author, recently for first time, a biphasic post - vaccinal following vaccination Covid 19 (Covishield), causing glycemic an elderly diabetes mellitus 2 (DM2) patient on who had moderate IR. observed patient, considered crucial clinical as, increase or decrease IR, could explain glycaemic disturbances. vaccine 19, have immunological basis. aspects briefly reviewed explore any possible interaction between two, that referred above. Also, underlying mechanisms disturbances, above-mentioned syndromes non-IR r explored as shed some light mechanism reported. A hypothesis suggested, taking into consideration, aforesaid observations. Apart from other unidentified factors might be reported, which account its paucity reporting, need investigated by future research.